Health, Biotechnology, and Pharmaceuticals
Photonics is proving to be a high-potential technology for meeting global public health objectives.
ALPhANOV builds on nearly 20 years of history, collaboration with its regional ecosystem, and roadmaps issued by global policymakers to shape its technology roadmap in health, biotechnology, and pharmaceuticals.
The solutions developed by the photonics sector in healthcare enhance the overall experience, from fundamental research to the patient’s lived experience.

For medical research, it brings new perspectives in medical imaging and early diagnosis.

For industrals, it enables the design of more efficient, precise, less invasive, and cost-effective medical devices and pharmaceutical products, while facilitating quality control.

For healthcare professionals, it improves the precision of interventions, thereby minimizing damage to healthy tissue.

For patients, it offers a safer, more comfortable, and, above all, more personalized overall experience.
Photonics technologies address health, biotech, and pharma in four main areas:





Medical Imaging & Diagnosis
See and detect with unmatched precision.
• Advanced optical imaging (OCT, fluorescence, spectroscopy) (TUMECS, MiMu, SAPHIRE, FASS)
• Early diagnosis of cancers (XPulse, Hekat), neurodegenerative diseases, infectious diseases
• Photonic sensors for biological analysis and real-time monitoring: optical sensors for air and water quality monitoring
Laser-Based Treatment & Surgery
Precise, targeted, and less invasive treatments: once limited to ophthalmic surgery, ALPhANOV has developed expertise in using lasers for both soft and hard tissue cutting.
• Laser surgery (ophthalmology, maxillofacial, dentistry, ENT, oncology)
• Photodynamic and photothermal therapies (tumor treatments)
• Optogenetics (SLALLOM)
Surface Engineering for Medical Devices
Laser processing revolutionize the manufacturing and customization of medical devices: lasers are also used for the production of implantable and non-implantable medical devices.
Given the current need to reduce the use of chemicals and preserve resources, laser technologies offer more sustainable alternatives. They enable surface functionalization, such as antibacterial treatment of titanium prostheses, without adding harmful substances. These processes also extend to the production of innovative devices like microfluidic chips.
• Additive manufacturing and laser micro-machining for medical devices
• Functionalization of implantable material surfaces (Newskin, Tresclean)
• Cutting and structuring of biomaterials
• Applications in bioprinting and the production of custom prostheses or implants
Light-Based Therapy & Well-being
Using light for gentler and more personalized medicine: ALPhANOV develops specific light sources with customized illumination geometries to treat and manage certain conditions.
• Photobiomodulation and light therapy for pain, depression, or neurological disorders
• Light-assisted cell regeneration and wound healing
• Effects of light on circadian rhythm and sleep quality
• Dermatology (PARACETAMOL)
All of this is supported by high-level training for healthcare professionals.
Training
Working in this environment requires knowledge of usage, safety, and risk assessment. The associated risks are numerous—for the patient, the medical team as a whole, and the practitioner: injuries, burns, tissue damage, and fire hazards.
To address these challenges, our training center PYLA develops dedicated programs for professionals.
Beyond Human Health
Photonics for health extends well beyond human health, offering technological solutions for plant and animal health as well.
Our center draws inspiration from the health strategies of global stakeholders to inform its technology roadmap and maximize the impact and sustainability of its activities.
Produits & Services
Linked collaborative projects
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LAMIPoC - Mass production of microfluidic devices
Analyzing the potential of ultra-fast (femtosecond) laser technology for the mass production of microfluidic devices.
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SAPHIRE – A device for online optical inspection
Improving the production quality and efficiency of pharmaceutical tablets and capsules by developing an innovative, multimodal and fully integrated in-line optical inspection device.
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CRYST^3 - Prototype of a new material based on individual alkali atoms
Developing a new fully-fiber prototype, based on the trapping and cooling of cold atoms in a hollow core fiber.
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LAMIPoC - Mass production of microfluidic devices
Analyzing the potential of ultra-fast (femtosecond) laser technology for the mass production of microfluidic devices.
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ExoFlow - Characterizing exosomes in real time
Designing and manufacturing an innovative biomedical instrument for real time characterizing of biological nano-objects such as exosomes or viruses.
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SLALLOM - Holographic microscope
To develop a holographic microscope for all-optical brain studies with a single laser source.
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XPulse - Innovative laser-generated X-ray medical imaging system
Developing a phase contrast mammography system based on x-ray source generated by laser and dedicated to the early detection of breast cancer.
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Atlantic-Ket-Med - Accompaniment of the biomedical sector
To establish a transnational advanced pilot manufacturing ecosystem for future biomedical products.
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PARACETAMOL - Picosecond laser source
To develop a protocol to remove tattoos by laser. In comparison with current tattoo removal techniques, this protocol will allow to remove colored tattoos with a reduction of pain and without side effects.
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PharmaSense - Manufacturing processes of medicines
(2015 - 2018)
Improve the manufacturing processes of medicines to meet the future costs, availability and safety challenges of medicines produces around the world.Learn more -
BONEPRINTING - Laser assisted bioimpression
(2011- 2015)
Laser assisted bioimpression for in vivo bone tissue engineering in mice.Learn more -
Blue laser - Development of blue fiber lasers
(2008 - 2012)
To develop a new family of high-power blue fiber lasers.Learn more
Publications
- Vascularization of Cell-Laden Microfibres by Femtosecond Laser Processing, I. Verit, L. Gemini, J. Preterre, P. Pfirmann, H. Bakis, J-C. Fricain, R. Kling, C. Rigothier - 2022
- Ablation of Bone Tissue by Femtosecond Laser: A Path to High-Resolution Bone Surgery, L. Gemini, S. Al-Bourgol, G. Machinet, A. Bakkali, M. Faucon, R. Kling
- Ablation of Bone Tissue by Femtosecond Laser: A Path to High-Resolution Bone Surgery - L. Gemini, S. Al-Bourgol , G. Machinet , A. Bakkali , M. Faucon, R. Kling
- Intra-volume processing of gelatine hydrogel by femtosecond laser-induced cavitation, I. Verit, L. Gemini, J.-C. Fricain, R. Kling & C. Rigothier
- Nonlinear imaging using a 35 fs 3.5 nJ all-PM fiber laser frequency doubled at 800 nm, C.-H. Hage, S. Boivinet, S. Vidal, G. Machinet, J. Boullet
- Prism-assembly for dual-band short-wave infrared region line-scan camera, B. Chassagne; L. de Laulanié; M. Pommiès
- Biofabrication of a vascular capillary by ultra-short laser pulses, I. Verit, C. Rigothier, L. Gemini, J. Preterre, C. Javaux-Leger; J.-C. Fricain, R. Kling